Showing posts with label Health News. Show all posts
Showing posts with label Health News. Show all posts

IS ALMOND MILK BAD FOR ENVIORNMENT?

IS ALMOND MILK BAD FOR ENVIRONMENT?

Over the past ten or so years, almond milk has grown in popularity. An increasing number of Americans are enjoying it straight from the carton or in recipes.

However, a lot of customers are curious if almond milk is harmful to the environment. It originates from thirsty trees, some of which were grown during California’s protracted drought. Here, we compare the amount of water used in the production of almond milk to that of dairy and other plant-based alternatives.

Describe Almond Milk.

Almond milk is a beverage prepared by blending and straining almonds along with water and, depending on the type of milk, a few other possible flavoring additives like sugar or vanilla.

Although the dairy industry opposes the sale of plant-based products labeled as “milk,” the term “milk” has always been associated with the resulting beverage. Not only has almond milk been mentioned in recipes going back at least to the 13th century, but plant-based milks are also included in the definition of the Oxford English Dictionary. Almond milk is, according to a recent FDA ruling, a milk. 


Is Environmental Damage Caused by Almond Milk?

In general, almond milk poses less of a threat to the environment than cow’s milk. However, there are a few things that buyers need to be aware of. 


What Are Almond Milk’s Environmental Drawbacks?

1. Use of Water

The amount of water used in almond production is among its worst features. Almonds require approximately 371 liters of fresh water per liter of milk, making them thirstier than other plants. That is still far less than dairy milk, but it is more than soy milk, oat milk, and even rice milk.

Unfortunately, California, which is particularly prone to drought, produces around 80% of the almonds planted worldwide. Although almond farming uses less water than dairy, it nevertheless contributes to the state’s droughts. Farmers in California are also switching to more water-efficient irrigation methods, which conserve water in comparison to methods from ten or twenty years ago.


2. Use of Pesticides

With more than 34 million pounds of active chemicals sprayed on almond trees in the United States in 2017—more than most other crops—almonds have a significant pesticide problem. An increase in pesticide use may be detrimental to local wildlife populations, particularly insects, as well as


 3. Effect on Honeybees

In particular, bees may be negatively impacted by all of these chemicals. Because of the potential harm that pesticides can cause to their bee colonies, some honeybee farmers think twice before planting almond trees.

Still, there’s space for development. In an effort to support nearby bees and pollinators, many almond tree groves are attempting to increase biodiversity by incorporating other types of plants.


Which Kind of Milk Is Worse for the Environment, Almond or Dairy?

Almond milk is less harmful to the environment than cow’s milk in practically every way. Actually, all plant-based milk varieties are more environmentally friendly than cow’s milk. 

How Come Almond Milk Is Superior to Dairy Milk?

Use of Land

Almond milk uses half a square meter of land per liter, compared to 8.95 square meters for dairy milk. Because animals require a lot of feed, animal agriculture is intrinsically inefficient in its use of land; just the cattle industry accounts for 41% of global deforestation. The dairy industry is not an exception to this pattern. 

Greenhouse Gases

Almond milk generates 0.7 kg of greenhouse emissions per liter, more than four times less than dairy milk’s 3.15 kg. As ruminant animals, cows release a significant amount of methane when housed in the large quantities needed for the dairy and beef sectors.


Use of Water

Dairy milk uses less water than almond milk, even though almond milk gets a lot of flak for it. Almond milk uses 371 liters of fresh water per liter, which is still high but not quite as much as 628 liters for dairy milk.

The largest water-guzzlers in the American West are feed crops, such as alfalfa and corn, which are fed to livestock like dairy cows. During a drought, the demands of animal husbandry on the water supply are enormous. Even if they exacerbate the issue, almonds still pose less of a threat than dairy, but more so than other plant-based milk alternatives.  


Other Issues

Additionally, the surplus nutrients that dairy milk washes into streams with the potential to harm aquatic life contributes to pollution. A large amount of pesticides are used in animal agriculture in order to develop feed crops.


What Are Some Almond Milk Substitutes?

Aisles full of milk options, ranging from different plant-based milks to cow’s milk, can be found in most supermarkets in the United States. Every one has a varied need for the use of water and land, and produces a different amount of emissions. 


Milk of Oats

  • The manufacturing of oat milk uses, per liter
  • 48.24 liters of water on 0.76 square meters of land
  • 0.9 kg of emissions of greenhouse gases

The bottom line is that oat milk is far less bad for the environment than almond or dairy milk. 



Is the Environment Affected by Soy Milk?

The manufacturing of soy milk uses, per liter:

  • 0.66 square meters of terrain
  • 27.8 water liters
  • 0.98 kg of emissions of greenhouse gases

Conclusion: Fortified soy milk provides the same nutrients as dairy milk, which is also fortified, and is among the best milks in terms of environmental effect. 



Is There Environmental Danger with Cashew Milk?

Because cashew milk is not as popular as other plant-based milks, experts have not yet thoroughly examined its life cycle assessments. Nonetheless, cashew production itself employs:

6,450 water gallons for every pound

7.6 grams per kilogram of greenhouse gas emissions

Assuming the amount of cashews used in many recipes found online, 130 grams per liter of milk comes to approximately:

131.9 water liters

A quantity of 0.988 kg of carbon dioxide

Sometimes, subpar labor techniques are used to make cashew milk. Furthermore, since cashews are a climate-specific crop, their overall carbon emissions are increased by transportation (though the production of food always contributes more to emissions than transportation). 


Is Environmental Damage Caused by Coconut Milk?

The manufacturing of coconut milk uses, per kilogram:

6.81 water liters

Emissions of greenhouse gases of 0.1 kg

There are occasions when the manufacturing of coconut milk is connected to deforestation in Southeast Asian nations. Additionally, because picking coconuts is a physically demanding task, workers’ rights are occasionally violated. It’s crucial to purchase fair trade or locally grown coconuts because of this.

Conclusion: Read origin labels carefully because coconut milk has been connected to deforestation.


Which Milk Is Best for the Environment?

It’s challenging to choose a single milk that is the greenest, but soy and oat milks are almost completely free of emissions, water pollution, and land use. It is also evident that dairy milk is the worst option; it is more harmful than plant-based milks in almost every manner.

Actions You Can Take

Fortunately, choosing a sustainable option can also mean choosing health, especially if you choose for something like soy that is fortified and unsweetened. If you decide to consume almond milk, be sure it was made with as little pesticide as possible by looking for the Bee Better seal. The main conclusion is that plant-based milks are obviously healthier for the environment and can also be a component of a balanced diet. 

 



 

 

Fifty years of vaccines that save lives: 154 million lives are saved by WHO's EPI

 Fifty years of vaccines that save lives: 154 million lives are saved by WHO’s EPI

MAY 7,2024

NR.BALOCH



Researchers have looked at the effects of the World Health Organization’s Expanded Program on Immunization (EPI) on public health, with findings published in The Lancet.

In 1974, the World Health Assembly committed itself to ensuring that everyone may benefit from vaccinations by establishing the Expanded Protection Index (EPI). By 1990, children were to be vaccinated against measles, poliomyelitis, smallpox, pertussis, tetanus, diphtheria, and tuberculosis, according to a WHO plan. As of right now, the EPI offers protection for all ages against other pathogens. The breadth of protection has significantly increased as a result of vaccination programs expanding to include more diseases.


Researchers modeled the effect of EPI on public health in the current study. They calculated the number of years of life gained, years of complete health acquired (i.e., disability-adjusted life-years averted), and years of life gained in WHO member states from June 1974 to May 2024 as a result of vaccination against 14 diseases.

The following diseases/pathogens were made vaccines against: rotavirus, poliomyelitis, rubella, invasive pneumococcal disease, tetanus, meningitis A, hepatitis B, yellow fever, diphtheria, Japanese encephalitis, pertussis, measles, poliomyelitis, and rubella. A uniform structure was created to evaluate the effect for each fully immunized person.

The group combined vaccination coverage estimates from the Vaccine Impact Modeling Consortium (VIMC), Immunization Dashboard, Supplementary Immunization Activities Database, and WHO’s Polio Information System. A total of 24 vaccination initiatives were assessed, divided into disease categories,


Firstly, impact estimates were obtained using the simulation of established measles and poliomyelitis transmission models for a 50-year timeframe. Second, from 2000 to 2024, VIMC transmission models for Japanese encephalitis, rotavirus, rubella, H. influenzae type B, and hepatitis B were expanded. Third, updated static disease burden models were created for diphtheria, tetanus, pertussis, and tuberculosis.

The three modeling approaches made it possible to capture vaccine effects at the individual and population levels. Estimating the effect of EPI on lives prevented, years of life gained, years of full health gained, and the percentage of infant mortality reduction related to vaccinations was the main goal of the study. These indicators were also assessed by the World Bank income stratum and region as secondary outcomes.


Results

According to the researchers, vaccination campaigns against the 14 infections prevented an estimated 154 million fatalities between June 1974 and May 2024, of which 146 million were prevented in children under the age of five. Nine billion life-years and 10.2 billion years of perfect health were also gained during this time. Gained were 58 years of life and 66 years of complete health on average.



Thanks to vaccinations, there have been fewer deaths, years of life preserved, and years of perfect health. The data spans the years 1974–2024. Measles: 93·7 million fatalities prevented, 5·7 billion years of life preserved, and 5·8 billion years of full health gained. Tetanus: 27·9 million fatalities prevented, 1·4 billion years of life preserved, and 1·4 billion years of good health gained. With pertussis, 1 billion years of complete health were acquired, 0.8 billion years of life were spared, and 13.2 million fatalities were prevented. 10·9 million deaths from tuberculosis are prevented; 0.6 billion years of life are preserved; and 0.9 billion years of good health are acquired. For Haemophilus influenzae type B, there were 2.78 million fewer fatalities, 0.2 billion more years of life saved, and 0.2 billion more years of good health gained. Poliomyelitis: 1·6 million fatalities prevented, 0·1 billion years of life saved, and years of


Notably, the prevention of poliomyelitis cases resulted in 0.8 billion years of increased health. The measles vaccination was the single most important factor in the 93.7 million lives that were saved over the course of 50 years in both World Bank income stratum and WHO areas. Additionally, since 1974, there has been a significant drop in infant mortality worldwide, with immunization directly contributing to 40% of this development.

If someone were to live to be 10, 25, or 50 years old in 2024, their chances of surviving the next year would be 44%, 35%, or 16% higher, respectively, than if they had not had any immunizations since 1974. The probability of surviving a life course increased most significantly in the African and Eastern Mediterranean regions, while it decreased most in the European zone. Upon


In conclusion

According to the research, vaccinations have prevented the deaths of an estimated 154 million people since 1974, the most of them (95%) were young children. This indicates that vaccinations have resulted in 10.2 billion extra years of healthy living and nine billion life-years saved. Interestingly, the measles vaccination was the single biggest factor.

Moreover, vaccinations accounted for about half of the decrease in infant mortality worldwide. As a result, the annual survival rate of a child born in 2024 will climb by 40%. Furthermore, the advantages of baby vaccination for survival last for more than 50 years. Areas with higher beginning mortality rates saw larger absolute advances at the expense of smaller relative gains. 


Journal citation: Sim SY, Johnson HC, Shattock AJ, et al. Improving health and survival via immunization: a 50-year retrospective of the Expanded Program on Immunization. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00850-X/fulltext The Lancet, 2024, DOI: 10.1016/S0140-6736(24)00850-X


In Patients With Chronic Liver Disease, Platelet Count to Prothrombin Time: A Noninvasive Predictor of Esophageal Varices

MAY 4,2024

NRBALOCH

Summary of Introduction

One potentially fatal side effect of portal hypertension in cirrhosis patients is esophageal variceal hemorrhage. The current study measured the platelet count to prothrombin time (PLT/PT) ratio for the assessment of portal hypertension and subsequent diagnosis of esophageal varices (EVs) in patients with chronic liver disease (CLD), even though upper gastrointestinal endoscopy is still the preferred method for EV identification.





Techniques

Using a non-probability consecutive sampling technique, this observational comparison study was carried out at the outpatient department of Patel Hospital in Karachi, Pakistan. The Patel Hospital Ethical Review Committee (PH/IRB/2022/028) granted ethical approval. For parametric data, an independent sample t-test was employed; for non-parametric data, the Mann-Whitney U test was utilized. The category data were compared using the chi-square test.


Outcomes

105 participants with and without EV participated in the trial. Thirty (66.7%) males and fifteen (33.3%) females did not have EV, while 38 (63.3%) males and 22 (36.7%) females did. Additionally, patients with EV had a substantially lower platelet (PLT) count (87.6 ± 59.8) than patients without EV (176.6 ± 87.7) (p < 0.001). those with EV had a PLT/PT ratio that was considerably lower (median: 5.04, IQR: 3.12-9.21) than those without EV (median: 14.57, IQR: 8.08-20.58) (p < 0.001). The PLT/PT ratio’s EV identification sensitivity and specificity were 97.80% and 83.30%, respectively.

In summary

In comparison to cases without EV, we observed a considerably decreased PLT/PT ratio in EV patients. PLT/PT demonstrated a good sensitivity in detecting cases with EVs in CLD after establishing an ideal threshold. Thus, we conclude that the PLT/PT ratio is a noninvasive predictor of the occurrence of EV in individuals with CLD.

Overview

Cirrhosis is the primary cause of morbidity and death worldwide. In 2016, it accounted for 2.2% of deaths and 1.5% of years of life with a disability adjusted for disability, making it the 11th most common cause of death and the 15th most prevalent cause of morbidity globally [1]. Chronic liver disease (CLD) claimed the lives of 1.32 million persons in 2017; nearly two-thirds of these deaths were in males and one-third in females [2]. Portal hypertension and related consequences, such as tissue scarring, mixed regenerating nodules, and liver cell degeneration, are caused by liver cirrhosis. Among Asian countries, Pakistan has the greatest incidence of CLD [3].

Clinically speaking, portal hypertension is defined as a pathological rise in portal vein pressure brought on by a number of factors, the most frequent of which being


Supplies & Techniques

Patient Choice
This non-probability consecutive sampling strategy was used in an observational comparison study conducted in the outpatient department of Patel Hospital in Karachi, Pakistan. The Patel Hospital Ethical Review Committee (PH/IRB/2022/028) granted ethical approval. Six months were dedicated to the study. Every patient has provided written consent. 105 male and female patients with liver cirrhosis between the ages of 30 and 55 were included in the study. The study excluded patients with hepatocellular carcinoma, gastrectomy, lower portal hypertension patients on medication, patients undergoing sclerotherapy, critically ill patients with liver cirrhosis, patients with past portosystemic anastomosis, and other variables associated with ascites.


Biochemical and clinical characteristics

Each patient received a comprehensive evaluation that included a clinical history, laboratory testing to assess liver and renal function, total blood count, PLT, PT, and the international normalized ratio (INR). Our completely automated chemical analyzer was utilized to quantify creatinine and urea. Every laboratory test was done at Patel Hospital’s clinical pathology department. After being calculated, the PLT/PT ratios were statistically examined. After being screened for EGD, the patients were divided into two groups according to whether or not they had EV.

Gastroscopy and abdominal ultrasonography

Every patient had upper gastroesophageal endoscopy for EVs screening in the endoscopy suite and abdominal ultrasonography in the radiology department. The treatments were carried out by skilled gastroenterologists and radiologists. The laboratory and clinical parameters were unknown to the sonologists or the endoscopists. The grading system used to categorize EV was based on size; varices in the mucosa were included in grade I; large varices that did not flatten with insufflation and occupied more than a third of the esophageal lumen were included in grade III; and varices covering more than two-thirds of the esophageal lumen were included in grade IV [16].

Data interpretation

IBM SPSS Statistics, version 26.0, was used to enter and analyze the data (IBM Corp., Armonk, NY). For quantitative variables, descriptive statistics are presented as means and standard deviations; for qualitative variables, the same is true for frequencies and percentages. The data’s normality was examined using the Shapiro-Wilk test. Patients with and without EV were compared for numerical variables; for parametric data, an independent sample t-test was employed, and for nonparametric data, a Mann-Whitney U test. To compare the categorical data of patients with and without EV, the chi-square test was employed. The PLT/PT ratio, sensitivity, specificity, and area under the curve (AUC) cutoff points were assessed using a receiver operating characteristic (ROC) analysis. An

Outcomes

Clinical, biochemical, and endoscopic characteristics of EV-positive and -negative individuals
105 participants with and without EV participated in the trial. There was no discernible variation in the gender distribution among them; 38 (63.3%) men and 22 (36.7%) females had EV, while 30 (66.7%) males and 15 (33.3%) females did not (p = 0.723). There was no significant difference (p = 0.899) in the mean age of patients with and without EV, which was 40.33 ± 15.98 years and 41.93 ± 12.72 years, respectively. Likewise, a negligible correlation was observed in the body mass index (BMI) between the two cohorts (p = 0.131). However, there was a notable difference in the etiology of cirrhosis across the groups (p = 0.029), with the hepatitis C virus being the predominant cause in 31 (51.7%) of the patients with EV. Individuals with EV show notably


ChangeablesEsophageal varices patients, n (%)/mean ± SDIndividuals free of gastric varices, n (%)/mean ± SDp-value
sex

38 males (63.3%)Thirty (66.7%)0.723

22 (36.7%) female; 15 (33.3%)

Years of age 40.33 ± 15.98(kg/m2) 41.93 ± 12.72~0.899 BMI22.26 ± 5.3422.01 ± 4.25<0.131

The cause of cirrhosis

HBV~5 (8.3%)Thirteen (28.1%)0.029* HCV~21 (46.7%)~31 (51.7%)

HBV+HDV~7 (11.7%)Six (13.3%)

Immune 5 (8.3%)2 (4.4%)

The remaining 5 (8.3%)Alcoholics: 3 (6.7%) 7 (11.7%) 0 (0.0%)

1.29 ± 0.20 < 1.13 ± 0.20 INR<0.001* Albumin 3.03 ± 0.687 mg/dL3.64 ± 0.640PLT/PT; median (IQR) 5.04 (3.12-9.21) 14.57 (8.08-20.58) <0.001* Portal vein diameter (cm) 1.12 ± 0.17 1.04 ± 0.18 0.038* Child-Pugh class A 24 (40.0%) 36 (80.0%)B~26 (43.3%) <0.001*Nine (20.0%)

0 (0.0%) C 10 (16.7%)

esophageal


Table 1 lists the etiology, grading, and demographic details of esophageal varices (n = 105).

*p-value at least 0.05 is significant. The information is shown as mean ± SD/median (IQR), n, and percentage.

Standard deviation (SD) and body mass index (BMI) Hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis D virus (HDV) are INR is the ratio that is internationalized. Interquartile range is known as IQR and platelet count to prothrombin time ratio as PLT/PT. 



Variations between individuals with and without EV in terms of hematological markers and renal and liver function tests

There was a significant correlation (p = 0.001) between the mean hemoglobin levels of patients with EV (10.28 ± 2.08 g/dL) and those without EV (11.66 ± 2.04 g/dL). Moreover, patients with EV had a significantly lower total leukocyte count (TLC) (4.47 ± 2.33) compared to those without (6.52 ± 2.16), with a highly significant difference (p < 0.001). Patients with EV had a substantially lower PLT (87.6 ± 59.8) than those without EV (176.6 ± 87.7) (p < 0.001). Furthermore, PT, urea, creatinine, and gamma-glutamyl transferase (GGT) levels between the two groups showed significant differences (p < 0.001). However, there were negligible variations in sodium levels, aspartate aminotransferase, alkaline phosphatase (ALP), and mean corpuscular volume (MCV).


ChangeablesEsophageal varices patients, n (%)/mean ± SDIndividuals without gastroesophageal reflux disease, n (%)/mean ± SDHb (g/dL) 10.28 ± 2.08 11.66 ± 2.04 0.001* Complete blood count

(×103/m3) total leukocyte count 4.47 ± 2.33 6.52 ± 2.16<<0.00187.6 ± 59.8~176.6 ± 87.7~<0.001 Platelet count (×103/mm3)* The mean corpuscular volume was 81.2 ± 7.95 against 81.6 ± 7.53 0.789.

Prothrombin time (sec) <0.001; 14.31 ± 2.62 <12.64 ± 2.97*

Test of renal function

(mg/dL) Urea<25.5 ± 18.16~51.22 ± 53.19~<0.001* Creatinine (milligrams/deciliter)~0.80 ± 0.64~2.26 ± 3.56~0.003* Sodium 133.6 ± 20.6 137.5 ± 4.91 0.738 (mEq/L)

Test of liver function

IU/L of alkaline phosphatase: 213.5 ± 180.7 ± 201.8 ± 193.7 0.534

(IU/L) aspartate aminotransferase 86.03 ± 65.7 59.6 ± 41.1 0.134

Alanine transaminase (IU/L) 48.9 ± 43.4~0.271 54.5 ± 33.7

(IU/L) Gamma-glutamyl transferase 72.5 ± 70.9~120.0 ± 155.7~<0.001*


Table 1: *P-value significant at <0.05, the etiology, grading, and demographics of esophageal varices (n = 105). The information is shown as mean ± SD/median (IQR), n, and percentage.

INR is for international normalized ratio; SD stands for standard deviation; BMI for body mass index; HBV for hepatitis B virus; HCV for hepatitis C virus; and HDV for hepatitis D virus. Platelet count to PLT/PT:Table 1: *P-value significant at <0.05, the etiology, grading, and demographics of esophageal varices (n = 105). The information is shown as mean ± SD/median (IQR), n, and percentage.

Standard deviation (SD) and body mass index (BMI) Hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis D virus (HDV) are INR is the ratio that is internationalized. Platelet count to prothrombin time ratio (PLT/PT); prothrombin time ratio (IQR): interquartile range; interquartile range


Variations between individuals with and without EV in terms of hematological markers and renal and liver function tests

There was a significant correlation (p = 0.001) between the mean hemoglobin levels of patients with EV (10.28 ± 2.08 g/dL) and those without EV (11.66 ± 2.04 g/dL). Moreover, patients with EV had a significantly lower total leukocyte count (TLC) (4.47 ± 2.33) compared to those without (6.52 ± 2.16), with a highly significant difference (p < 0.001). Patients with EV had a substantially lower PLT (87.6 ± 59.8) than those without EV (176.6 ± 87.7) (p < 0.001). Furthermore, PT, urea, creatinine, and gamma-glutamyl transferase (GGT) levels between the two groups showed significant differences (p < 0.001). However, there were negligible variations in sodium levels, aspartate aminotransferase, alkaline phosphatase (ALP), and mean corpuscular volume (MCV).


ChangeablesEsophageal varices patients, n (%)/mean ± SDIndividuals without gastroesophageal reflux disease, n (%)/mean ± SDHb (g/dL) 10.28 ± 2.08 11.66 ± 2.04 0.001* Complete blood count

(×103/m3) total leukocyte count 4.47 ± 2.33 6.52 ± 2.16<<0.00187.6 ± 59.8~176.6 ± 87.7~<0.001 Platelet count (×103/mm3)* The mean corpuscular volume was 81.2 ± 7.95 against 81.6 ± 7.53 0.789.

Prothrombin time (sec) <0.001; 14.31 ± 2.62 <12.64 ± 2.97* Test of renal function

(mg/dL) Urea<25.5 ± 18.16~51.22 ± 53.19~<0.001* Creatinine (milligrams/deciliter)~0.80 ± 0.64~2.26 ± 3.56~0.003* Sodium 133.6 ± 20.6 137.5 ± 4.91 0.738 (mEq/L)

Test of liver function

IU/L of alkaline phosphatase: 213.5 ± 180.7 ± 201.8 ± 193.7 0.534

(IU/L) aspartate aminotransferase 86.03 ± 65.7 59.6 ± 41.1 0.134

Alanine transaminase (IU/L) 48.9 ± 43.4~0.271 54.5 ± 33.7

(IU/L) Gamma-glutamyl transferase 72.5 ± 70.9~120.0 ± 155.7~<0.001



Table 2 shows the differences in complete blood counts, liver and renal function tests, and esophageal varices comparing patients with and without the condition. *p-value significant at <0.05. The information is displayed as n, %/mean ± SD.

The hepatic and renal function tests as well as the total blood count were compared between individuals with and without esophageal varices in SDTable 2. *p-value significant at <0.05. The information is displayed as n, %/mean ± SD.


Standard deviation (SD) and hemoglobin (Hb) are two different concepts.


PLT/PT ratio’s sensitivity and specificity in detecting EV

According to the receiver operator characteristic curve, the PLT/PT ratio is a significant predictor of EV, with an AUC of 0.823 indicating good discriminative ability and an extremely substantial correlation (p < 0.001). 2.5487 was the ideal cutoff value for the PLT/PT ratio. Table 3 and Figure 1 demonstrate the sensitivity and specificity of the PLT/PT ratio for EV identification, which were 97.80% and 83.30%, respectively.

Talk

To diagnose portal hypertension, a number of diagnostic procedures are available. Directly measuring portal pressure is an intrusive procedure. Therefore, a minimally invasive approach like an upper gastrointestinal tract endoscopy is preferred [17]. The gold standard for diagnosing gastroesophageal varices is still upper gastrointestinal endoscopy (UGIE), but in patients with CLD, the ratio of PLT/PT may be important for evaluating portal hypertension and EV.

A prospective study evaluating the impact of PT on EV initiation was carried out in Bangladesh. A total of sixty liver cirrhosis patients were split into two groups at random: group I consisted of thirty patients with EV, and group II consisted of thirty patients without EV. The mean age of the 60 patients was 37.11 ± 14.81 years, with 11 females and 49 men. The hepatitis B virus was primarily detected in cirrhosis in 43 (71.7%) instances. One patient (1.6%) was afflicted by Wilson’s sickness; twelve patients (20%) were neither B or C; and four instances (6.6%) had the hepatitis C virus (HCV). It was discovered that there was a positive correlation between EV and the longer plasma PT (four seconds) with a sensitivity of 56.67% and a specificity of 73.33% [17]. This research

The frequency and features of EV in patients with liver cirrhosis who received UGIE were further examined in a different retrospective analysis carried out in Pakistan. 92.6% of the 2089 patients had EV, whereas 7.45% did not. 766 (39.5%) instances had grade I EV, 465 (24%) had grade II EV, and 703 (36.4%) had grade III EV. UGIE was performed on a total of 1331 (63.7%) male and 758 (36.3%) female liver cirrhosis patients. 89.1% of the patients who were female had EV overall, compared to 94.6% of the patients who were male. The likelihood of experiencing EV was significantly higher in males (p < 0.01). The mean age of patients diagnosed with EV (51.25 ± 10.03 years) was found to be significantly different from that of patients diagnosed with no EV (49.26 ± 11.11 years).


In a similar vein, 110 patients participated in this cross-sectional descriptive study that was carried out in Pakistan; 49 (44.5%) of the patients were female, and 61 (55.5%) were male. The average age of the patients was 59.89 +/- 9.01 years. The PLT was less than 50,000/uL in 39 (35.5%) of the patients, with the range being between 50,000-99,000/uL in 29 (26.4%), 100,000-150000/uL in 14 (12.7%), and >150,000/uL in 28 (25.5%) patients. Overall, grade I EV was present in 26 (23.6%) of the patients, whereas grades II–IV EV were seen in 27 (24.5%), 37 (33.6%), and 20 (18.2%) of the patients [21]. These results aligned with those of a Taiwanese study that demonstrated male dominance in cirrhotic patients, with 71% of patients being male [22]. The current investigation supported these conclusions and showed that the majority of


Several prior studies used PLT in combination with other noninvasive indicators such as the AST to platelet ratio index (APRI) and the platelet count/spleen diameter ratio (PC/SD ratio) to predict the grading of EV and the necessity for endoscopy in patients with cirrhosis [23]. The PLT/PT ratio was utilized in this investigation because it is easily accessible, noninvasive, reasonably priced, and resource-efficient. Furthermore, no specific knowledge is needed.

It’s interesting to note that a different study evaluated the noninvasive EV markers’ diagnosis accuracy in cirrhosis patients. That investigation found that the PC/SD ratio’s optimal cutoff value was ≤818 and that its sensitivity and specificity were, respectively, 92.05% and 60% (AUC: 0.835) [24]. A different Chinese study with a 73% positive response rate likewise used PSDR <909 as a cutoff number.



In a similar vein, one study evaluated the PLT/PT ratio’s and the PC/SD ratio’s capacity to assess the incidence of EV in Egyptian patients with cirrhosis associated with ≤HCV. 99 patients had liver cirrhosis associated with HCV, of which 41 did not have EV and 58 did not have bleeding EV. The PLT/PT ratio at cutoff ≤9419.3 (AUC: 0.936) was shown to be a more effective test for EV detection than the PLT/SD ratio at cutoff ≤993.75 (AUC: 0.888), according to analyses of receiver operator characteristics. Comparing the PLT/PT ratio to the PLT/SD ratio, the PLT/PT ratio showed superior sensitivity, specificity, PPV, and NPV (95.31, 88.57, 93.8, and 91.2% vs. 89.06, 85.71, 91.9, and 81.1%, respectively) [27]. The current investigation revealed a highly significant p-value and an AUC of 0.823.

Restrictions

This research has certain restrictions. Only cirrhotic patients were included in this short, single-centered investigation. Despite the fact that numerous studies have shown that the PC/SD ratio is a more accurate way to estimate the size and grading of varices, we only employed PLT to evaluate the grading of varices. Cherry red patches, or other indicators of recent or impending bleeding, were not seen in this investigation. It is advised that future multicenter research employ the spleen size ratio, early bleeding symptoms, and a particular cirrhosis cause. To validate the findings, more prospective studies with a larger sample size are required.


In conclusion

PLT/PT was observed to be considerably lower in patients with EVs who had underlying CLD in this study. We discovered that the PLT/PT value had a high sensitivity and specificity in recognizing EVs after establishing an ideal cutoff. Therefore, the results suggest that the PLT/PT ratio is a noninvasive marker of EV occurrence in CLD patients. To create a prediction score and look at other markers and predictors of esophagogastric variceal bleeding, more research is required.


Citations

Cheemerla S, Balakrishnan M: Chronic liver disease: worldwide epidemiology. 10.1002/cld.1061 in Clin Liver Dis (Hoboken), 2021, 17:365–70.

Sepanlou SG, Safiri S, Bisignano C, et al.: A comprehensive analysis for the Global Burden of Disease Study 2017 of the national, regional, and worldwide burden of cirrhosis by cause in 195 countries and territories, 1990-2017. 2020; 5:245–26; 10.1016/S2468-1253(19)30349-8; Lancet Gastroenterol Hepatol.

Genetic predisposition to chronic liver disease in Pakistani individuals Raja AM, Ciociola E, Ahmad IN, et al. 2020, 21:3558 in Int J Mol Sci. 10.3390/ijms21103558

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New Study Highlights the Importance of a Balanced Diet for Brain Health

 Introduction



Convenience often takes precedence over nutrition in our fast-paced environment. New research, however, confirms the unquestionable connection between brain health and food decisions. The brain is the organ in the body that uses the most energy, therefore it needs a constant flow of nourishment to perform at its best.

Dietary Influence on Brain Health




The saying “you are what you eat” is especially applicable to your brain. Every bite you bite into shapes your emotions, memory, and cognitive abilities. Important nutrients that serve as building blocks for brain cells include omega-3 fatty acids, which are present in nuts and fish and which support neurotransmitter function and synaptic plasticity.

Effects of Poor Diet on Brain Health

On the other hand, a diet deficient in vital nutrients may cause problems for the health of the brain. Diets heavy in processed foods, saturated fats, and refined sugars may hasten cognitive aging and raise the risk of neurodegenerative illnesses like Alzheimer’s, according to research. 

 

A Balanced Diet’s Benefits for the Brain

 

Adopting a healthy, well-balanced diet full of nutrients that support brain function has several advantages. It improves memory and cognitive function while strengthening the brain’s resistance to age-related decline and neurodegenerative diseases.


Important Elements for Mental Wellness 



 

A few nutrients stand out for having a significant effect on brain function. Omega-3 fatty acids are found in large amounts in walnuts and fatty fish like salmon. They are well known for their anti-inflammatory qualities and for supporting brain transmission. Colorful fruits and vegetables are rich sources of antioxidants, which work to combat dangerous free radicals that can damage brain tissue. B vitamins are also essential for the synthesis of neurotransmitters and for cognitive function.


Resources for Nutrients That Boost the Brain


Including foods high in nutrients in your diet is essential for maintaining brain function. A wide variety of meals, such as crisp kale and sumptuous salmon, provide an abundance of nutrients that support the brain. Aim to incorporate whole grains, lean meats, healthy fats, and a rainbow of fruits and vegetables into your meals.

 Tips for Maintaining a Brain-Healthy Diet

 Maintaining a brain-healthy diet doesn’t have to be daunting. Start by embracing variety and color in your meals, opting for whole foods over processed alternatives. Minimize your intake of sugary snacks and refined carbohydrates, opting instead for nutrient-dense options that nourish both body and mind.


The Brain’s Health and the Mediterranean Diet

 

The Mediterranean diet is one eating style that excels in fostering brain health. Full of heart-healthy fats, lean meats, and fresh veggies, this diet has received a lot of praise for its positive effects on cognition. A Mediterranean-style diet has been linked to improved brain function and a lower risk of cognitive decline, according to research.


Other Lifestyle Factors for Brain Health

Although nutrition is crucial for maintaining brain function, it is only one aspect of the whole. Maintaining cognitive vigor also requires practicing stress management techniques, getting enough sleep, and exercising on a regular basis. You can protect your brain against the effects of aging by treating your body and mind as a whole.


Conclusion

In a time of sensory overload and information overload, it is more important than ever to prioritize brain health. This ground-breaking study shows that you are the first step towards cognitive vitality. You may strengthen your brain’s resilience and flourish at every stage of life by implementing a healthy lifestyle and eating a balanced diet full of nutrients that are known to promote cognitive function. 

 

 Frequently Asked Question(FOQ)

1. How does diet impact brain health? 

A: Diet plays a pivotal role in shaping cognitive function, memory, and mood by supplying essential nutrients crucial for brain health. 

 

2. What are some key nutrients for brain health? 

A: Omega-3 fatty acids, antioxidants, and B vitamins are among the key nutrients vital for maintaining optimal brain function.

3. Can dietary choices affect the risk of neurodegenerative diseases? 

A: Yes, diets high in processed foods, saturated fats, and refined sugars may increase the risk of neurodegenerative diseases like Alzheimer’s. 

 

4. What is the Mediterranean diet, and how does it benefit brain health? 

A: The Mediterranean diet emphasizes fresh produce, lean proteins, and healthy fats, offering cognitive benefits and reducing the risk of cognitive decline.

5. What lifestyle factors besides diet are important for brain health? 

A healthy lifestyle is essential for maintaining cognitive vigor and general brain health. These elements include regular exercise, getting enough sleep, and managing stress.

 

Scientists work to make healthier white bread

MAY 1 ,2024

BY NR.BALOCH 

                                

Scientists Work to Make Healthier White Bread

 Introduction




Bread is a cherished food item that is a mainstay in many diets around the world due to its versatility and ease of use. Because of its mild flavor and smooth texture, white bread has long been a favorite among bread varieties. However, doubts over its nutritional worth have damaged its reputation. Scientists are putting up endless effort to develop healthier alternatives to white bread that are still aesthetically pleasing and provide better nutritional value in response to these obstacles.

 Challenges with White Bread

White bread has been criticized for having a high glycemic index and little fiber, yet being very popular. Regular use of white bread has been connected to health problems like diabetes, heart disease, and weight gain. Furthermore, refining eliminates some of the vital elements found in whole grains, producing a product with little nutritious value.

Scientific Innovations





In order to overcome the drawbacks of conventional white bread, scientists have started using novel ingredients and baking methods. A possible strategy is to use other flours, like chickpea, coconut, or almond flour. Compared to refined wheat flour, these flours have higher levels of protein and fiber and are naturally gluten-free.

 Benefits of Using Alternative Flours

Almond flour is a nutrient-dense option for baking bread because it’s high in protein, healthy fats, and vitamin E. Because coconut flour has a high fiber content and a low carb content, it can be used by people on low-carb diets. Compared to regular wheat flour, chickpea flour is nutrient-dense, filling, and full of fiber and protein.




 Impact of Fiber-Rich Additives

Scientists are investigating the use of fiber-rich additions in addition to substitute flours to improve the nutritional profile of white bread. Bread can have more fiber without losing flavor or texture by using ingredients such resistant starch, oat fiber, and psyllium husk. These supplements support healthy digestion, assist control blood sugar, and increase feelings of fullness.




 Role of Technology

Technological developments have been instrumental in the creation of healthier white bread. Sourdough fermentation and gradual proofing are two modern baking methods that can enhance the nutritional value and digestibility of bread. Moreover, automation and high-precision machinery guarantee constant quality and lower the possibility of human error in the manufacturing process.

 Automation for Consistent Quality

Manufacturers can keep tight control over the bread-making process thanks to automated mixing, kneading, and baking technologies, which produce bread with a consistent texture and flavor. Measures for ensuring quality, like controlling humidity and temperature, guarantee that every loaf satisfies the required requirements for flavor and freshness.

 Consumer Preferences

There’s been a discernible move toward better bread options as consumer awareness of health and wellbeing grows. While flavor and texture are still crucial considerations when choosing bread, a growing number of consumers increasingly place more importance on ingredient transparency and nutritional value. Manufacturers have reformulated their goods and introduced healthier substitutes for classic white bread in response to this shift in consumer tastes.

 Importance of Taste and Texture in Bread

In the realm of bread, flavor and texture are still quite important, even with the focus on nutrition. In order to attract consumers, healthier white bread variants need to find a balance between taste and nutritional value. The newest developments in texture optimization and flavor profiling guarantee that healthy options taste and satisfy just as well as their more traditional equivalents.




 Environmental Considerations

Concerns about bread’s nutritional value are not the only environmental effects that are becoming more well known. In the baking sector, sustainable measures like using less energy and using organic ingredients are becoming more and more crucial. Furthermore, reducing food waste at every stage of the supply chain aids in lessening the environmental impact of bread production.

Reducing Food Waste

Bread is one of the most wasted food items globally, with millions of tons discarded each year. To combat this issue, manufacturers are exploring creative solutions such as upcycling surplus bread into new products or partnering with food banks to redistribute unsold inventory. By reducing food waste, the industry can contribute to a more sustainable and environmentally friendly future.  

 Future Prospects

Looking ahead, the future of white bread lies in continued innovation and research. Researchers are looking at new ingredients and ways to make bread that will increase its nutritional content without sacrificing its consumer appeal. Furthermore, bread preferences and dietary demands can be tailored by individuals thanks to developments in personalized nutrition.

Potential for Personalized Nutrition

Bread products that are customized to an individual’s genetic predispositions and specific health goals may become available soon thanks to personalized nutrition technology like microbiome analysis and genetic testing. This customized approach to nutrition has the potential to lower the risk of diet-related diseases and improve overall health outcomes.

 Conclusion

To sum up, the pursuit of creating healthier white bread is a complex undertaking that takes into account advancements in science, technology, and customer preferences. Through the use of substitute ingredients, adoption of environmentally friendly procedures, and an emphasis on nutritional value, researchers and producers have the potential to completely transform the bread market. White bread appears to have a brighter and healthier future than it did a few years ago with continuous research and customer backing.

FAQs

 Is whole wheat bread always healthier?

For many people, whole wheat bread is a better alternative to white bread because it typically has more minerals and fiber. But since everyone’s nutritional requirements and preferences are different, it’s important to take taste and texture into account while selecting bread.

 Can white bread ever be completely healthy?

Though whole wheat bread still offers more nutritional value than standard white bread, innovations in baking techniques and component formulation have produced healthier alternatives. White bread types with higher nutritional content can be produced by producers by utilizing fiber-rich additions, alternative flours, and sustainable procedures. 

 What impact do additives have on nutritional content? 

By boosting fiber content and supplementing vital nutrients, additives like vitamins and fiber-rich substances can improve the nutritional value of bread. To avoid artificial substances or overprocessing, which might offset some of the health benefits, it’s crucial to select additives wisely. 

 Are there any white bread options that are gluten-free?

Yes, there are gluten-free alternatives to traditional white bread made from

Doctor reveals how to reduce your risk of getting dementia - and the one early symptom you should never ignore

1. Introduction

    – Why Dementia Prevention Matters

2. Understanding Dementia

    – What is Dementia?

    – Types of Dementia

3.The Lifestyle’s Impact on the Risk of Dementia  

    – Diet and Nutrition

    – Exercise and Physical Activity

 – Social connections and emotional well-being – Cognitive engagement and mental stimulation

4. Medical Factors and Dementia Risk

    – Hypertension and Heart Health

    – Diabetes and Blood Sugar Management

    – Sleep Disorders

5. The Significance of Prompt Identification

    – Recognizing Early Signs and Symptoms

    – Seeking Medical Evaluation

6. Tips for Dementia Prevention

  – Eating a Diet that Is Brain-Healthy – Continuing My Physical Activity

    – Engaging in Cognitive Challenges

    – Cultivating Social Connections

7. The One Sign of Early Age You Must Never Ignore

    – Memory Loss vs. Normal Aging

    – When to Seek Medical Attention

8. Conclusion

Now, let’s proceed with the article itself:

Medical Professionals Explain How to Lower Your Chance of Developing Dementia – And the One Early Sign You Should Never Ignore




A growing global concern, dementia affects millions of people and their families. Fortunately, there are actions you may take to lower your chance of contracting this crippling illness. This post will provide the most recent information from medical professionals on protecting your brain’s health and seeing any red flags early on.

Understanding Dementia

 The word “dementia” refers to a group of cognitive deficits that interfere with day-to-day functioning rather than a single illness. The most prevalent variety of dementia is Alzheimer’s disease, although there are other varieties as well, such as Lewy body and vascular dementia.Each type has its own set of symptoms and progression.

The Lifestyle’s Impact on the Risk of Dementia 

 

According to research, a person’s lifestyle has a big impact on how likely they are to get dementia. Maintaining a nutritious diet, getting regular exercise, engaging in mental stimulation, and socializing with others can all assist to maintain cognitive function and lower the risk of cognitive decline. 

 

Diet and Nutrition Studies have shown a correlation between a diet high in fruits, vegetables, whole grains, and lean proteins with a decreased risk of dementia. Foods rich in omega-3 fatty acids, antioxidants, and vitamins B and D are very good for the brain. 

  

Physical Activity and Exercise: Consistent physical activity has a significant impact on brain function in addition to maintaining physical fitness. Aim for 150 minutes or more per week of moderate-to-intense aerobic exercise in addition to  

  

Mental Stimulation and Cognitive Engagement: Keep your brain active by challenging yourself with puzzles, games, reading, or learning a new skill. Activities that require problem-solving, memory recall, and critical thinking can help to build cognitive reserve and protect against dementia.

  

Social Connections and Emotional Well-being: Maintaining strong social ties and emotional support networks is crucial for mental health. Stay connected with friends, family, and community groups to combat feelings of loneliness and isolation, which are associated with an increased risk of dementia.

Medical Factors and Dementia Risk

Apart from lifestyle decisions, certain medical disorders can also affect mental well-being and heighten the likelihood of developing dementia.

 

Heart Health and Hypertension: Heart disease and elevated blood pressure are recognized risk factors for dementia. Protecting brain function can be achieved by controlling hypertension with medication and lifestyle modifications. 

  

Diabetes and Blood Sugar Management: Diabetes raises the risk of dementia and cognitive impairment. For the sake of brain health, blood sugar levels must be maintained within a healthy range via food, exercise, and medication. 

  

Sleep Disorders: Dementia and cognitive impairment have been related to inadequate sleep and untreated sleep disorders, such as sleep apnea. To promote brain function, make proper sleep hygiene a priority and seek treatment for any sleep-related conditions. 

 

The Significance of Prompt Identification

 

Earlier  Tips for Dementia Prevention

A brain-healthy lifestyle can greatly lower the incidence of dementia and postpone the onset of cognitive decline, even though dementia cannot be completely avoided. 

 

Eating a Brain-Healthy Diet: Make sure your diet is rich in whole grains, fruits, vegetables, lean meats, and healthy fats. Reduce your consumption of sugar, processed foods, and saturated fats as they can cause oxidative stress and inflammation in the brain.

  

Remaining Physically Active: Make exercise a regular part of your daily schedule. Try to combine aerobic, strength, and flexibility training. Engaging in physical activity increases blood flow to the brain, stimulates neuronal growth, and guards against cognitive impairment brought on by aging. 

  

Taking on Cognitive Challenges: Engage in activities that demand mental work and concentration to keep your brain active. Attempt  

Conclusion

In summary, lowering the chance of dementia necessitates a multipronged strategy that includes early detection, prompt intervention, medical therapy of underlying diseases, and good lifestyle choices. You can take control of your brain health and lower your risk of dementia by eating a brain-healthy diet, exercising regularly, fostering social relationships, and getting medical attention for any worrisome symptoms. 

 

Frequently Asked Questions (FAQs)

1. Can dementia be prevented entirely?

 Although there is no surefire strategy to stop dementia, leading a healthy lifestyle and taking care of underlying medical issues can greatly lower the risk and postpone the start. 

  

2. How does dementia differ from Alzheimer’s disease?

 While Alzheimer’s disease is a particular kind of dementia marked by increasing cognitive impairment and memory loss,